GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11174436 | 1 | rs11174458 | chr12:62788098 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.66 | 0.000262 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs17101923 | 1 | rs11175967 | chr12:66321344 | LLPH | chr12:66516850-66563807:- | 0.15 | 3.81 | 0.000144 | Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth) |
| BRCA | cis | rs7726354 | 1 | rs111773762 | chr5:56269336 | MAP3K1 | chr5:56110900-56191976:+ | -0.25 | -4.23 | 2.59E-5 | Breast cancer (early onset) |
| BRCA | cis | rs111803315 | 1 | rs111803315 | chr14:59965293 | C14orf149 | chr14:59939406-59951126:- | -0.24 | -3.49 | 0.000507 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs111803315 | chr14:59965293 | JKAMP | chr14:59951161-59972080:+ | 0.33 | 5.73 | 1.28E-8 | Schizophrenia |
| BRCA | cis | rs4118325 | 1 | rs11185056 | chr1:107578610 | PRMT6 | chr1:107599267-107601907:+ | 0.22 | 4.06 | 5.23E-5 | AIDS |
| BRCA | cis | rs4118325 | 1 | rs11185057 | chr1:107596964 | NTNG1 | chr1:107682629-108024471:+ | 0.17 | 3.74 | 0.000197 | AIDS |
| BRCA | cis | rs4118325 | 1 | rs11185057 | chr1:107596964 | PRMT6 | chr1:107599267-107601907:+ | 0.23 | 4.61 | 4.53E-6 | AIDS |
| BRCA | cis | rs4118325 | 1 | rs11185058 | chr1:107603269 | PRMT6 | chr1:107599267-107601907:+ | 0.18 | 3.74 | 0.000193 | AIDS |
| BRCA | cis | rs11185790 | 1 | rs11185773 | chr10:91349331 | FLJ37201 | chr10:91451057-91457685:- | -0.2 | -4.32 | 1.7E-5 | Metabolic traits |
| BRCA | cis | rs11185790 | 1 | rs11185780 | chr10:91363624 | FLJ37201 | chr10:91451057-91457685:- | 0.21 | 4.49 | 7.79E-6 | Metabolic traits |
| BRCA | cis | rs11185790 | 1 | rs11185790 | chr10:91372533 | FLJ37201 | chr10:91451057-91457685:- | 0.16 | 3.55 | 0.000398 | Metabolic traits |
| BRCA | cis | rs11185790 | 1 | rs11185792 | chr10:91374967 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.73 | 0.0002 | Metabolic traits |
| BRCA | cis | rs11185790 | 1 | rs11185793 | chr10:91375224 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.76 | 0.000178 | Metabolic traits |
| BRCA | cis | rs11185790 | 1 | rs11185794 | chr10:91375419 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.76 | 0.000178 | Metabolic traits |